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Overviews
Selective Hemapheresis, an Effective New Approach in the
Therapeutic Management of Disorders Associated With Rheological Impairment: Mode
of Action and Possible Clinical Indications
Schuff-Werner P, Holdt B.
Artif Organs. 2002;26:117-123.
Low-Density Lipoprotein Apheresis in the Treatment of Atherosclerosis
and Other Potential Uses
Moriarty PM, Gibson CA.
Curr Atheroscler Rep. 2001;3:156-162.
HELP Apheresis in the Treatment of Sepsis
Samtleben W, Bengsch S, Boos KS, Seidel D.
Artif Organs. 1998;22:43-46.
Safety and Effectiveness of Long-Term LDL-Apheresis in
Patients at High Risk
Thiery J, Seidel D.
Curr Opinion Lipidol. 1998;9:521-526.
Abstracts
Activity of Thrombocytes as a Marker of Sufficient
Intensity of LDL-Apheresis in Familial Hypercholesterolemia
Blaha M, Pecka M, Urbankova J, et al.
Transfus Apheresis Sci. 2004;30:83-87.
The use of extracorporal elimination for selective removal of LDL-C in severe familial
hypercholesterolemia is the treatment of choice. Still, there are no suitable markers
for selective elimination of LDL-C, which would reliably determine the therapy intensity
immediately after the procedure. A report states that platelet aggregability may
be a marker, but this was unsuccessfully tested. As a result, the methods were modified
and changes were determined.
Click for full abstract.
Heparin-Mediated Extracorporeal Low-Density Lipoprotein
Precipitation: Rationale for a Specific Adjuvant Therapy in Cardiovascular Disease
Blessing F, Wang Y, Walli AK, Seidel D.
Transfus Apheresis Sci. 2004;30:255-266.
LDL-apheresis in hypercholesterolemic patients is the most promising and safest
therapy when compared with various radical measures, including liver transplantation.
The authors review the heparin-induced method as a valuable therapeutic tool for
the treatment and prevention of early graft occlusion after CABG, sudden hearing
loss, stroke, and preeclampsia.
Click for full abstract.
The HELP System for the Treatment of Atherothrombotic Disorders: A Review
Jaeger BR.
Ther Apher Dial. 2003;7:391-396.
This review underscores recent developments in chronic and single application of
apheresis in cardiology with specific emphasis on potential applications, including
myocardial infarction, stroke, and following coronary artery bypass grafting.
Click for full abstract.
Selective Hemapheresis, an Effective New Approach in the Therapeutic Management
of Disorders Associated With Rheological Impairment: Mode of Action and Possible
Clinical Indications
Schuff-Werner P, Holdt B.
Artif Organs. 2002;26:117-123.
In this comprehensive review, the rheological effects of a single LDL-apheresis
treatment using different devices are compared. The selectivity of the extracorporeal
methods yield different effects on the rheologically relevant plasma proteins; thus,
their rheological effectiveness substantially differs. Cited studies recognize the
effectiveness of the extracorporeal methods in treating various diseases, among
them, sudden hearing loss and cerebrovascular conditions.
Click for full abstract.
Evidence for Maximal Treatment of Atherosclerosis: Drastic Reduction of Cholesterol
and Fibrinogen Restores Vascular Homeostasis
Jaeger BR.
Ther Apher. 2001;5:207-211.
This article summarized the clinical and biochemical evidence for maximal treatment
of atherosclerosis by a simultaneous 60% to 70% reduction of plasma LDL cholesterol,
fibrinogen, and lipoprotein a (LPa) concentrations with statins and LDL-apheresis
using the heparin-induced method. Potential future applications are also discussed.
Click for full abstract.
C-Reactive Protein and Other Markers of Inflammation Among Patients Undergoing
HELP LDL Apheresis
Moriarty PM, Gibson CA, Shih J, Matia MS.
Atherosclerosis. 2001;158:495-498.
This trial of familial hypercholesterolemic patients treated with LDL-apheresis
therapy using the heparin-induced method evaluates the short- and long-term effects
on C-reactive protein (CRP). After 6 months of therapy, pretreatment hsCRP showed
an overall mean level decrease of 49%, suggesting that LDL-apheresis rapidly decreases
serum hsCRP levels in the long term.
Click for full abstract.
The Role of LDL Apheresis in Lipid Lowering Therapy for Hyperlipidemic Patients
Lane DM, Bricker LA, Schuff-Werner P.
Current Opinion in Cardiovascular, Pulmonary & Renal Investigational Drugs.
2000;2:216-222.
This review determines that the addition of LDL-apheresis to lipid-lowering drug
therapy in hyperlipidemic patients can reduce pretreatment levels and produce lower
between-treatment levels of LDL cholesterol than lipid-lowering drug therapy alone.
Full abstract not available.
Heparin-Mediated Extracorporeal LDL/Fibrinogen Precipitation—HELP—in
Coronary and Cerebral Ischemia
Jaeger BR, Marx P, Pfefferkorn T, Hamann G, Seidel D.
Acta Neurochir Suppl . 1999;73:81-84.
LDL-apheresis using the heparin-induced method is beneficial in the prevention and
therapy of myocardial infarction. This method is now studied in patients with cerebral
infarction. The heparin-induced method was found to be safe in patients with coronary
heart disease and allows controlled reduction of thrombogenic plasma compounds.
Click for full abstract.
Therapeutic Effects of LDL Apheresis in the Prevention of Atherosclerosis
Kajinami K, Mabuchi H.
Curr Opin Lipidol . 1999;10:401-406.
The efficacy and safety of LDL-apheresis has already been established for lipid
lowering in patients with refractory hypercholesterolemia. Two reports described
excellent long-term follow-up results for patient with coronary artery disease who
had been treated with LDL-apheresis using dextran sulfate cellulose columns plus
lipid-lowering therapy.
Click for full abstract.
Status of Treatment of Vascular Dementia
Lechner H.
Neuroepidemiology. 1998;17:10-13.
Further improvement of dementia could be achieved by application of the LDL-apheresis
using the heparin-induced method to enhance the effect of hemorheologically active
drugs. Using the heparin-induced method, LDL, cholesterol, triglycerides, and fibrinogen
can be considerably lowered and may result in clinical improvement or slowing of
the progression of vascular dementia.
Click for full abstract.
Application of HELP in Nonarteritic Anterior Ischemic Optic Neuropathy: A Prospective,
Randomized, Controlled Study
Haas A, Walzl M, Jesenik F, et al.
Graefes Arch Clin Exp Ophthalmol. 1997;235:14-19.
In a controlled study over a period of 3 months, 40 patients with nonarteritic ischemic
optic neuropathy (NAION) were randomly assigned to either LDL-apheresis via the
heparin-induced method or hemodilution therapy to determine the efficacy of these
two treatments on visual acuity and fields. Results show that the heparin-induced
method seems to be safe and more effective than hemodilution in improving the hemorheological
and the functional situation in NAION.
Click for full abstract.
Aggressive Lowering of Fibrinogen and Cholesterol in the Prevention of Graft
Vessel Disease After Heart Transplantation
Jaeger BR, Meiser B, Nagel D, et al.
Circulation. 1997;96(suppl 9):II-157-II-158.
Combination therapy with statins and LDL-apheresis via the heparin-induced method
is given to heart transplant patients to determine whether drastic lowering of fibrinogen,
LDL-C, and Lp(a) prevent graft vessel disease (GVD). Results demonstrate that combined
treatment prevents GVD in 9 of 10 patients.
Click for full abstract.
Regression of Transplant Coronary Artery Disease During Chronic Low-Density
Lipoprotein-Apheresis
Park J-W, Merz M, Braun P.
J Heart Lung Transplant. 1997;16:290-297.
In long-term heart transplantation survivors with hyperlipidemia who have development
of a rapid progressive coronary artery disease, LDL-apheresis can encourage disease
regression.
Click for full abstract.
Haemorheological Intervention by Heparin-Induced Plasma Protein Precipitation
in Patients With Acute Occlusion of the Central Retinal Artery or With Ischemic
Neuropathy of the Optical Nerve
Schuff-Werner P, Lauritzen K, Arens B, Vogel M.
Jpn J Apheresis. 1997;16:239-240.
The results of this study will, for the first time, determine whether interventional
haemorheo-therapy using heparin-induced precipitation of rheologically relevant
plasma proteins is clinically superior to conventional haemodilution.
Full abstract not available.
HELP for the Treatment of Different Atherosclerotic Diseases
Walzl M, Walzl B, and the HELP Study Group.
Jpn J Apheresis. 1997;16:237-238.
The authors review various diseases in which LDL-apheresis therapy via the heparin-induced
method may be applied, including cerebrovascular disease and ocular microcirculatory
disorders.
Full abstract not available.
Additional Citations
In Vitro and In Vivo Studies With Different Precipitate Filter Cartridges for
HELP-LDL-Apheresis: Optimization of Precipitate Filter Cartridges
Morsch G, Maywald F, Wanner C.
Bioseparation. 1995;5:11-18.
Click for full abstract.
The Impact of HELP on Haemorheology in Peripheral Arterial Disease
Lechner P, Walzl M, Walzl B.
Clin Hemorheol. 1994;14:181-188.
Full abstract not available.
Does LDL-Apheresis in Steroid-Resistant Nephrotic Syndrome Affect Prognosis?
Muso E, Yashiro M, Matsushima M, Yoshida H, Sawanishi K, Sasayama S.
Nephrol Dial Transplant. 1994;9:257-264.
Click for full abstract.
Results of a Two-Month Follow-Up After Single Heparin-Induced Extracorporeal
LDL Precipitation in Vascular Dementia
Walzl M, Walzl B, Lechner H.
J Stroke Cerebrovasc Dis. 1994;4:179-182.
Full abstract not available.
Reverse Flux Filtration: A New Mode of Therapy Improving the Efficacy of Heparin-Induced
Extracorporeal LDL Precipitation in Hyperlipidemic Hemodialysis Patients
Bosch T, Samtleben W, Thiery J, Gurland HJ, Seidel D.
Int J Artif Organs. 1993;16:75-85.
Click for full abstract.
Long-Term Efficiency, Biocompatibility, and Clinical Safety of Combined Simultaneous
LDL-Apheresis and Haemodialysis in Patients With Hypercholesterolaemia and End-Stage
Renal Failure
Bosch TH, Thiery J, Gurland HJ, Seidel D.
Nephrol Dial Transplant. 1993;8:1350-1358.
Click for full abstract.
The Influence of the HELP System on Yield Shear Stress in Vascular Disease
Kowal P, Walzl M, Walzl B, Lechner H.
Clin Hemorheol. 1993;13:701-706.
Full abstract not available.
HELP Application in Multi-Infarct Dementia
Lechner H, Walzl M, Walzl B, Kleinert G, Freidl W.
J Stroke Cerebrovasc Dis. 1992;2:228-231.
Full abstract not available.
Simultaneous Heparin Extracorporeal LDL Precipitation and Hemodialysis: First
Clinical Experience
Eisenhauer T, Muller U, Schuff-Werner P, et al.
ASAIO Trans. 1991;37:M494-M496.
Click for full abstract.
Combined LDL Apheresis and Hemodialysis in a Patient With End-Stage Renal Disease
and Accelerated Coronary Atherosclerosis
Grutzmacher P, Vallbracht C, Scheuermann E, Kurz P, Schoeppe W.
ASAIO Trans. 1991;37:M435-M436.
Click for full abstract.
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