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Overviews
Selective Hemapheresis, an Effective New Approach in the
Therapeutic Management of Disorders Associated With Rheological Impairment: Mode
of Action and Possible Clinical Indications
Schuff-Werner P, Holdt B.
Artif Organs. 2002;26:117-123.
Fibrinogen and LDL Apheresis in Treatment of Sudden Hearing
Loss: A Randomized Multicentre Trial
Suckfüll M, for the Hearing Loss Study Group.
Lancet. 2002;360:1811-1817.
Low-Density Lipoprotein Apheresis in the Treatment of Atherosclerosis
and Other Potential Uses
Moriarty PM, Gibson CA.
Curr Atheroscler Rep. 2001;3:156-162.
Safety and Effectiveness of Long-Term LDL-Apheresis in
Patients at High Risk
Thiery J, Seidel D.
Curr Opinion Lipidol. 1998;9:521-526.
Abstracts
Heparin-Mediated Extracorporeal Low-Density Lipoprotein
Precipitation: Rationale for a Specific Adjuvant Therapy in Cardiovascular Disease
Blessing F, Wang Y, Walli AK, Seidel D.
Transfus Apheresis Sci. 2004;30:255-266.
LDL-apheresis in hypercholesterolemic patients is the most promising and safest
therapy when compared with various radical measures, including liver transplantation.
The authors review the heparin-induced method as a valuable therapeutic tool for
the treatment and prevention of early graft occlusion after CABG, sudden hearing
loss, stroke, and preeclampsia.
Click for full abstract.
The HELP System for the Treatment of Atherothrombotic Disorders: A Review
Jaeger BR.
Ther Apher Dial. 2003;7:391-396.
This review underscores recent developments in chronic and single application of
apheresis in cardiology with specific emphasis on potential applications, including
myocardial infarction, stroke, and following coronary artery bypass grafting.
Click for full abstract.
Heparin-Induced Extracorporeal Low-Density Lipoprotein Precipitation
Mellwig KP.
Ther Apher Dial. 2003;7:365-369.
The heparin-induced method of LDL-apheresis improved coronary vasodilatation capacity
within 24 hours, producing significant reductions in total cholesterol, LDL-C, and
fibrinogen.
Click for full abstract.
Selective Hemapheresis, an Effective New Approach in the Therapeutic Management
of Disorders Associated With Rheological Impairment: Mode of Action and Possible
Clinical Indications
Schuff-Werner P, Holdt B.
Artif Organs. 2002;26:117-123.
In this comprehensive review, the rheological effects of a single LDL-apheresis
treatment using different devices are compared. The selectivity of the extracorporeal
methods yield different effects on the rheologically relevant plasma proteins; thus,
their rheological effectiveness substantially differs. Cited studies recognize the
effectiveness of the extracorporeal methods in treating various diseases, among
them, sudden hearing loss and cerebrovascular conditions.
Click for full abstract.
Evidence for Maximal Treatment of Atherosclerosis: Drastic Reduction of Cholesterol
and Fibrinogen Restores Vascular Homeostasis
Jaeger BR.
Ther Apher. 2001;5:207-211.
This article summarized the clinical and biochemical evidence for maximal treatment
of atherosclerosis by a simultaneous 60% to 70% reduction of plasma LDL cholesterol,
fibrinogen, and lipoprotein a (LPa) concentrations with statins and LDL-apheresis
using the heparin-induced method. Potential future applications are also discussed.
Click for full abstract.
Heparin-Induced Extracorporeal Low-Density Lipoprotein Precipitation Apheresis:
A New Therapeutic Concept in the Treatment of Sudden Hearing Loss
Suckfüll M.
Ther Apher. 2001;5:377-383.
This review presents rationale for using LDL-apheresis therapy via the heparin-induced
method in patients with sudden hearing loss, underscoring study data that demonstrates
better recovery among these patients with a single apheresis when compared with
conventional treatment for 10 days.
Click for full abstract.
Clinical Utility of LDL-Apheresis in the Treatment of Sudden Hearing Loss: A
Prospective, Randomized Study
Suckfüll M, Thiery J, Schorn K, Kastenbauer E, Seidel D.
Acta Otolaryngol. 1999;119:763-766.
This study sought to assess the effect of LDL-apheresis via the heparin-induced
method in removing LDL-cholesterol, fibrinogen, and lipoprotein (a) from the plasma
in patients with sudden hearing loss. Compared with standard therapy, the heparin-induced
method significantly reduced LDL-cholesterol, fibrinogen, and lipoprotein (a).
Click for full abstract.
Fibrinogen Lowering by Apheresis: Efficiency of Different Methods and Possible
Clinical Implications
Schuff-Werner P, Schütz E, Beyer H-J.
Jpn J Apheresis. 1997;16:317-318.
Five LDL-/fibrinogen-apheresis systems are compared based on their effects on rheologically
relevant plasma proteins, particularly on fibrinogen, and the resulting rheological
improvement. Plasma exchange, double filtration, and LDL-apheresis via the heparin-induced
method are the most effective fibrinogen-lowering apheresis procedures.
Full abstract not available.
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